Peer-reviewed literature on the CyberKnife® System is accumulating rapidly. Below is a list of papers published in respected medical journals describing CyberKnife treatment throughout the body, along with a brief summary for each. Click on the links to see each paper’s full reference and abstract located online (most on PubMed, a medical research search site maintained by the U.S. National Library of Medicine and the National Institutes of Health).

Intracranial

Staged stereotactic irradiation for acoustic neuroma. Chang et al. 2005. Stanford researchers show that fractionated treatment using the CyberKnife System for acoustic neuromas may improve hearing preservation.
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Robotically guided radiosurgery for children. Giller, et al. 2005. Researchers from Baylor University Medical Center used the CyberKnife System to achieve local control for children with some types of CNS tumors.
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Visual field preservation after multisession CyberKnife radiosurgery for perioptic lesions. Adler, et al. 2006 Stanford University researchers used the CyberKnife System to obtain high rates of tumor control for tumors near (less than 2 mm from) the optic apparatus; over 90% of patients treated maintained or improved their vision.
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Stereotactic radiosurgery using CT cisternography and non-isocentric planning for the treatment of trigeminal neuralgia. Lim et al. 2006. Researchers from Stanford University used the CyberKnife System to treat trigeminal neuralgia.  Ninety percent of patients treated rated their pain control as excellent with limited facial numbness at 10 months follow-up.
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Stereotactic radiosurgery of the postoperative resection cavity for brain metastases. Soltys, et al. 2007. Researchers from Stanford University used the CyberKnife System for adjuvant treatment of brain metastases by targeting post-resection cavities. They obtained a 79% local control rate at 12 months, which compares favorably to historic whole brain radiation treatment results.
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A volumetric study of CyberKnife hypofractionated stereotactic radiotherapy as salvage for progressive malignant brain tumors: initial experience. Giller et al. 2007. Researchers from Baylor University Medical Center used the CyberKnife System to perform fractionated stereotactic radiosurgery on lesions that are difficult to treat in a single fraction approach.
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Survival following CyberKnife radiosurgery and hypofractionated radiotherapy for newly diagnosed glioblastoma multiforme. Lipani et al. 2008. Researchers from Stanford University performed CyberKnife System treatment on 20 GBM patients after tumor resection. The overall median survival was 16 months, which compares favorably to post-surgical external beam radiation therapy.
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